Although Christian Heilmann covers what he wished he knew about JavaScript earlier, he actually points out the features JavaScript developers should know: shortcut notations, JSON, native JavaScript functions, event delegation, anonymous functions and the module pattern, allowing configuration, and using good libraries to abstract away browser differences.
Christian Heilmann lays out seven rules to better unobtrusive JavaScript, including not making assumptions about JavaScript, the browser and the document. Work with structured markup. If you are traversing a document, maybe there's a solution that can take advantage of CSS's selector mechanism instead. Work with browsers and users. Better understanding of events, and playing nice with namespace, scope, and patterns. And of course, think about the next developer, so keep the code maintainable.